I've been trying to mold myself into the Getting Things Done (GTD) mindset, but struggling with respect to email management. Pay It Forward Email Management (PIFEM) is a method similar to GTD designed for use with Microsoft Outlook. I've decided to give this a try, and so far, it's looking like it might work for me.
http://blogs.msdn.com/ianpal/archive/2008/06/03/email-task-and-time-management-with-pifem.aspx